Essays /

Lab Report Synthesis Organic Aspirin First Year Chemistry Essay

Essay preview

The Synthesis of Organic Aspirin


The purpose of this experiment was to find out how a reaction undergoes for a globally known painkiller called aspirin, and to become familiar with achieving successful yields. Aspirin is synthesized from salicylic acid and acetic anhydride. Those two chemicals are mixed together along with sulfuric acid to form a crude solid. Filtration is used separate the impurities from the crude aspirin. To get purified aspirin, the precipitate was heated until all the excess had been removed. The end product is pure dry aspirin. Though there was too much room for error the yield percentage will almost never be a hundred percent.


In 1897 Felix Hoffman synthesized acetylsalicylic acid when he was treating is father with today's so called aspirin due to his suffering of arthritis. It was known that aspirin had some side effects that were caused by the level of acid in the aspirin itself, which made the stomach irate when ingested. Hoffman reduced the acid by mixing the aspirin with sodium salicylate, a extract found in the willow tree bark [1], which paved the way to today's most popular and inexpensive drug [2].

Aspirin is the common name given to acetylsalicylic acid, sometimes abbreviated as ASA. ASA is considered to be an organic acid since it is composed of Carbon, Hydrogen, and Oxygen which also contains the carboxyl functional group-COOH. Pure ASA can be synthesized by treating salicylic acid with acetic anhydride in the presence of a trace of either sulfuric (in our case) or phosphoric acids. The complete reaction of ASA is shown in Figure 1.1 on page 2. Figure 1 shows the reaction for the synthesis of aspirin.

Figure 1: Salicylic Acid + Acetic Anhydride ( ACETYLSALICYLIC ACID + Acetic Acid


There were plenty of chemicals that were used in this experiment. Table 1 shows all chemicals used in the experiment and the source of them. For more depth look at the chemi...

Read more


-3 1 1.1 1.2 1.5 100 1256587865.unknown 1256623966.unknown 1256623987.unknown 1256624019.unknown 1256624031.unknown 1256624038.unknown 1256624170.unknown 1256624235.unknown 1256624665.unknown 1256624846.unknown 1256625017.unknown 1256625205.unknown 1256625211.unknown 1256625226.unknown 13 14 1897 1998 2 2007 3 4 5 50 6 abbrevi abstract accident acet acetylsalicyl achiev acid actual ad affect agent allow almost alon along also amount analyt anhydrid ann anywher appendix appli arthriti asa aspirin attent back balanc bark base basic becom burett calcul call came carbon carboxyl case catalyst caus chem1111/3 chemic chemistri close closer cold common complet compos conclus consid constant consum contain contamin contrast cooh cool could crude cylind d data decim decreas densiti depart depth descript determin discuss dissolv distil divid done dri drop dropper drug due easi educ effect either emb end enough equat equation.3 equip error ethanol except excess experi experiment explain extract eye familiar far father faulti felix figur filter filtrat find first five follow fomo form found function g gave get give given global graduat gram group group-cooh happen heat helmenstin hoffman hot howev human hundr hydrogen iii impur inaccur inc incorrect inexpens inflat ingest introduct irat john journal keep knob known lab laboratori lead least let level like limit list longer look loss made make mani manual mari mass mean measur might millilit minor mix mixtur ml molar mole molecular molli much multipli must name necessari need neglig never new nov number obvious oct odd old olmst one one-to-on organ oxygen page painkil paper pave pay pearson percent percentag period ph phosphor place plate pleas plenti poor popular possibl powder precipit precis predict presenc procedur process product provid pure purifi purpos put quantiti ran rather ratio reactant reaction reagent reason record recryst reduc refer remain remedi remov report result room salicyl scoopula scrape see seem separ show shown side simpli sinc sit smaller sodium solid solut solv sometim sourc start still stomach substanc success suffer sulfur suppli synthes synthesi tabl take theoret think though time today togeth trace treat treatment tree turn twice two unchang undergo univers unreact us use valu volum want warm water way weigh weight well willow winnipeg would xx year yield