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14 Ss204 09 Ch8 Essay

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ISB
 204
 SS14
 
Lecture
 9;
 February
 11,
 2014
 

1
 

2
 

Creutzfeld-­‐Jacob
 disease
 

•  A
 prion
 disease
 
•  Prions
 are
 misfolded
 proteins
 
•  Prions
 are
 infec8ous:
 can
 be
 transferred
 from
 
organism
 to
 organism,
 and
 ‘convert’
 normal
 proteins
 
•  Results
 in
 ‘plaques’
 of
 proteins
 and
 holes
 in
 brain
 
8ssue
 
3
 

Last time

Figure 5.16-1

Lower
 solute
 concentra  

ATP
 
Higher
 solute
 concentra  signal
 transduc5
 

Chapter 8

Cellular Reproduction: Cells from Cells
6
 

Last time

7
 

Last time
Chromosome (one
long piece of DNA)
Centromere

Centromere
Sister
chromatids

Duplicated chromosome

8
 

Last time

S phase
(DNA synthesis; chromosome duplication)

Figure 8.6
Interphase: metabolism and
growth (90% of time)
G1

G2

Mitotic
(M) phase:
cell division
(10% of time)

Cytokinesis
(division of
cytoplasm)

Mitosis
(division
of nucleus)

9
 

THE CELL CYCLE AND MITOSIS
Objec8ves:
 
•  Outline
 the
 stages
 of
 the
 cell
 cycle,
 describing
 
the
 events
 that
 occur
 (figure
 8.6)
 
•  Describe
 the
 checkpoints
 of
 the
 cell
 cycle,
 what
 
is
 ‘checked’,
 and
 what
 happens
 if
 a
 cell
 ‘fails’
 a
 
checkpoint
 
•  Outline
 the
 stages
 of
 mitosis,
 describing
 the
 
events
 that
 occur
 during
 each
 stage
 (Figure
 8.7)
 

 
10
 

The Cell Cycle

•  Highly
 controlled
 
–  Ensures
 there
 are
 no
 errors
  mostly
–  Ensures
 condi8ons
 are
 right
 for
 cell
 division
 

•  Cell
 cycle
 control
 is
 via
 proteins
 
–  Cyclins
 
Bind to
–  Cylin-­‐dependent
 kinases
 
–  Integrate
 informa8on
 from
 the
 enviro...

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Keywords

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