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Cancer Side Effects Prediction Essay

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2013 IEEE 15th International Conference on e-Health Networking, Applications and Services (Healthcom 2013)

Clinical-based Prediction of Side Effects in Colon
Cancer Chemotherapy
Mouna Kacimi

Ognjen Savkovi´c

Manfred Mitterer

Faculty of Computer Science
Free University of Bozen-Bolzano
I-39100 Bozen-Bolzano, Italy
[email protected]

Faculty of Computer Science
Free University of Bozen-Bolzano
I-39100 Bozen-Bolzano, Italy
[email protected]

Hospital Franz Tappeiner
I-39012, Meran-Merano, Italy
[email protected]

Abstract—Chemotherapy is used to treat cancer by killing
malignant cells or stopping them from multiplying. However, it can also harm healthy cells, which causes side effects. Some of the side effects of chemotherapy do not pose a serious threat to patients’ health. But, some others can be very serious such as the rapid fall in white blood cells making the patient vulnerable to serious infections. Different approaches have been proposed in the literature to predict the probability of experiencing a certain side effect on a specified day of each cycle of the chemotherapy. In our work, we are interested in predicting the side effects a patient is more likely to experience in each cycle. To this end, we take a different approach where we propose a predictive

model based on patient clinical information, such as concomitant diseases and medications. We have analyzed data from from 75 patients under FOLFOX chemotherapy for colon cancer. The
results show that our model improves the prediction accuracy compared to previously proposed time-based approaches. The
goal of this work is to help healthcare professionals in identifying possible side effects before starting a chemotherapy and taking the necessary actions to improve the quality of the treatment.

I.

I NTRODUCTION

A. Motivation
Cancer is a class of diseases characterized by a growth of
abnormal cells that divide uncontrollably and manage to move throughout the body destroying healthy tissue. According to
the World Health Organization [20], cancer is becoming a
leading cause of death worldwide accounting for 7.6 million
deaths (around 13% of all deaths) in 2008. These numbers are projected to continue rising, with an estimated 13.1 million deaths worldwide in 2030. Hence, research targeting cancer
prevention and treatment is of a vital importance. For this
reason, many efforts were invested over the last decades
to improve the quality of medical treatments leading to an
increase of the event free and overall survival rate. More
specifically, adjuvant chemotherapy, employed after tumor removal surgery, was proven to help reducing the recurrence risk of some types of cancer [18], [19]. However, chemotherapy
can damage healthy cells along with cancer cells. Patients
receiving chemotherapy may experience significant side effects, especially if polychemotherapy is used, that could have a negative impact on their quality of life and daily living [17], [1]. Moreover, side effects can influence the overall survival [5] leading in some cases to mortality [10]. To address this problem, a comprehensive study of the causes of side effects is necessary to provide an effective prediction of their occurrence. In this way, health care professionals can take the necessary

978-1-4673-5801-9/13/$26.00 ©2013 IEEE

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actions to alleviate the discomfort and anxiety of patients. Moreover, they can tailor the treatment depending on the
patient’s vulnerability to side effects for having a better control on his reactions to the chemotherapy.
B. Related Work
The problem of chemotherapy side effects have called
for the use of technology as a mean of communication
between professionals and patients. The goal is to improve
the symptom control and achieve a better quality of life by
reducing the hospitalizations rate and cost [12], [11], [7]. A practical example of the use of technology in cancer care is the Advanced Symptom Management System [8], [14], [6],
[15]. It consists of a mobile telephone-based remote symptom monitoring system which can be used to register, monitor and predict the side-effects of chemotherapy while the patient is not with a healthcare professional [4]. In this kind of systems, patients are asked to complete a symptom questionnaire on a

mobile phone on daily basis and sent this information directly to their hospital-based healthcare professional. Self-care advice is then given on the basis of the reported symptoms. All
information collected from patients during their chemotherapy is then exploited to develop predictive models for side effects. Examples of this models include the work by Maguire et. al., [13] that aims at estimating the probability of experiencing each symptom on a specified day of treatment, for patients

with breast cancer. This study shows that the probability
of experiencing a specific symptom is time dependent. Its
tendency is to have a peak effect, around the day in which
the treatment is received by patients, and an inverted U-shape effect rising from a low on the day after treatment to a
peak around mid-cycle before falling again. This work has
been improved and generalized to other types of cancer by
Mazzocco et. al., [16].
Very few approaches have looked at patient characteristics
and clinical information to predict side effects. The work by Dranitsaris et. al., [3] proposes a regression model based on patient information to estimate cardiotoxic risk for patients with metastatic breast cancer. Their study has shown that

characteristics such as patient age and weight and the number of cumulative cycles are good predictors for having cardiac
toxicity. Similarly, Kuderer et. al., [10] show that patient characteristics, type of malignancy, comorbidities, and infectious complications are useful in identifying patients at increased risk of serious medical complications and mortality associated

2013 IEEE 15th International Conference on e-Health Ne...

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